How often are you working on a biological question with more question marks than answers?

The answer is 'almost always' over here :) But that's when we pull structural information, experimental or computational, to break the system into its parts and think through the potential why's behind the protein function and biological behavior we're observing. It helps to go to the basics, especially when you're working on systems at the boundary of what is known. You don't have a clear path in the literature, so you have to pave your own way. Structural information and the physical principles behind protein function are powerful tools in crafting a set of testable hypotheses that create a defined, charted paths forward.

So when in doubt, go to structure!