Our Services

No matter the project, we provide protein engineering and science support with the dedication and drive of an in-house team member. We work seamlessly with your team to help you achieve your goals.

We’re invested in your success and we’re in it for the long haul.

Antibody Discovery and Engineering

From target identification to therapeutic candidate selection, there's a lot (and a lot of proteins!) required to run a successful antibody discovery pipeline. At Tyrala Consulting, we're well-versed in taking projects from inception through to lead antibody selection. We can help you generate the necessary protein reagents, design and run a binder or antibody campaign, and identify, characterize, and engineer hits for lead candidate selection. We  often work with our clients as their in-house antibody engineer, managing the protein science arm of their program to bridge discovery and early development so that they can advance molecules towards the clinic with confidence. 


We also work with teams in a more limited capacity to assess the sequence and structure of their current antibody or de novo-designed protein therapeutic to identify potential liabilities or production issues that could hinder later stage development. We provide risk mitigation strategies and  guide teams through this optimization process.

The Antibody Discovery Funnel

Tyrala Consulting guides you through this process. Here’s where we help:

Antibody Campaign

  • Target assessment and selection

  • Antigen design, production, and quality assessment

  • Antibody campaign study design and management

  • Clone sequence assessment and positive clone selection

Hit Identification

  • Small-scale recombinant production

  • Antigen affinity and specificity assessment

  • CDR sequence liability analysis

Hit Validation

  • Antigen affinity: Binding kinetics

  • Epitope binning

  • Epitope mapping

  • Evaluation and optimization of antibody production and solution behavior (aggregation propensity, yield, purity)

  • Functional assessment (potency, internalization, ADCC, etc)

  • Modality selection (ADC, radiotherapeutic, bispecifics)

Engineering and Developability

  • Reformatting, Isotype selection, Humanization

  • Fc functionalization

  • Affinity maturation/dematuration

  • Sequence and structural liability identification and risk mitigation

Are you ready to select a development candidate?

The path to development starts with understanding potential obstacles. Our Therapeutic Liability Assessment helps you transition your molecule from discovery to development by identifying potential liabilities and mapping out actionable risk mitigation strategies. 
Want to dig into the analysis details? Request a free copy of our Therapeutic Liability Assessment report, and schedule a complimentary call to discuss your project specifics. 
Have a de novo-designed therapeutic protein? Even better! Let's see how your molecule stacks up against industry standards!

Explore more of Tyrala x Antibody Discovery

We’re always up for a good challenge!

Lets discuss the details,